CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25522
Family Name Sodium channel protein type 5 subunit alpha and Sodium channel protein type 9 subunit alpha ligand 4-[[4-[7-[(2-fluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole family
No. of Seeds 15 No. of Other Members 8
Family Centroid CFAMM00474687 Functional Category Bioactive
Superfamily Sodium channel protein type 9 subunit alpha and Sodium channel protein type 5 subunit alpha Binder Superfamily 2
Class Class 3551

Cousin Family NamesSeedsMembers
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Heat shock protein HSP 90-alpha inhibitor 3-[2-amino-4-chloro-... 7 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 2 11
Sodium channel protein type 9 subunit alpha and Sodium channel... 1 0
Metabotropic glutamate receptor 5 ligand N-[2-[(3-chlorophenyl... 1 4
Glucose-dependent insulinotropic receptor ligand propan-2-yl 4... 1 0
Glucokinase inhibitor 4-methyl-N-[3-phenylmethoxy-5-(pyridin-2... 1 8
Nuclear receptor ROR-gamma and Neuropeptide S receptor ligand ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00474678 CHEMBL2012266 Bioactive 4-[[4-[7-[(3-methylphenyl)methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474671 CHEMBL2012180 Bioactive 4-[[4-(7-benzyl-5-fluoropyrrolo[2,3-d]pyrimidin-4-yl)oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474684 CHEMBL2012274 Bioactive 4-[[4-[7-[(2,6-difluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474670 CHEMBL2012285 Bioactive 4-[[4-(7-benzylpyrrolo[2,3-d]pyrimidin-4-yl)oxypiperidin-1-yl]methyl]-2-methyl-1,3-thiazole
CFAMM00474683 CHEMBL2012178 Bioactive 4-[[4-(7-benzyl-5,6-dimethylpyrrolo[2,3-d]pyrimidin-4-yl)oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474682 CHEMBL2012179 Bioactive 4-[[4-(7-benzyl-5-methylpyrrolo[2,3-d]pyrimidin-4-yl)oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474675 CHEMBL2012262 Bioactive 4-[[4-[7-[(2-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474688 CHEMBL2012273 Bioactive 4-[[4-[7-[[2-fluoro-3-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474681 CHEMBL2012268 Bioactive 4-[[4-[7-[[2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474674 CHEMBL2012263 Bioactive 4-[[4-[7-[(3-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474687 CHEMBL2012259 Bioactive 4-[[4-[7-[(2-fluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474686 CHEMBL2012272 Bioactive 4-[[4-[7-[(3-chloro-2-fluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474679 CHEMBL2012265 Bioactive 4-[[4-[7-[(2-methylphenyl)methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474672 CHEMBL2012181 Bioactive 4-[[4-(7-benzyl-5-chloropyrrolo[2,3-d]pyrimidin-4-yl)oxypiperidin-1-yl]methyl]-1,3-thiazole
CFAMM00474685 CHEMBL2012271 Bioactive 4-[[4-[7-[(2,3-difluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-4-yl]oxypiperidin-1-yl]methyl]-1,3-thiazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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