CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25533
Family Name Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imidazol-5-yl)acetyl]amino]-N-(4-phenoxyphenyl)-3-phenylmethoxypropanamide family
No. of Seeds 4 No. of Other Members 7
Family Centroid CFAMM00474725 Functional Category Bioactive
Superfamily Beta-2 adrenergic receptor and Histamine H3 receptor Binder Superfamily
Class Class 3281

Cousin Family NamesSeedsMembers
Insulin receptor Ligand Insulin, Porcine Family 61 205
14-alpha sterol demethylase Inhibitor Terconazole Family 4 46
Renin Inhibitor Remikiren Family 100 126
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Eluxadoline family 4 85
Renin Inhibitor Enalkiren Family 56 44
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Pol polyprotein and Renin inhibitor U-75875 family 12 1
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16g... 1 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 4 6
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 1 0
Putative NP ZINC40310254 Family 74 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00474727 CHEMBL2018465 Bioactive (2S)-N-[4-(4-chlorophenoxy)phenyl]-2-[[2-(1H-imidazol-5-yl)acetyl]amino]-3-phenylmethoxypropanamide
CFAMM00474726 CHEMBL2018467 Bioactive (2S)-N-[4-(4-fluorophenoxy)phenyl]-2-[[2-(1H-imidazol-5-yl)acetyl]amino]-3-phenylmethoxypropanamide
CFAMM00474725 CHEMBL2018460 Bioactive (2S)-2-[[2-(1H-imidazol-5-yl)acetyl]amino]-N-(4-phenoxyphenyl)-3-phenylmethoxypropanamide
CFAMM00474731 CHEMBL2016597 Bioactive (2S)-N-[4-(3-chlorophenoxy)phenyl]-2-[[2-(1H-imidazol-5-yl)acetyl]amino]-3-phenylmethoxypropanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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