CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2555
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 3A ligand SureCN3686079 family
No. of Seeds 9 No. of Other Members 19
Family Centroid CFAMM00235732 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 3A Binder Superfamily
Class Class 824

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Histamine H4 receptor Ligand A-943931 Family 14 11
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 13 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 6 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 0
Poly [ADP-ribose] polymerase 1 inhibitor 2-[2-[4-(1H-indazol-3... 1 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZBAK family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Tyrosine-protein kinase JAK2 inhibitor SureCN2455673 family 1 0
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Translocator protein inhibitor N-(4-chlorophenyl)-N-methyl-2-(... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
Corticotropin-releasing factor receptor 1 ligand 2-[6-(dimethy... 1 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 1
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Substance-P receptor ligand Netupitant family 5 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Transient receptor potential cation channel subfamily V member... 57 4
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Glutamate receptor 1 and Glutamate receptor 2 ligand cp-465022... 1 6
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[4-oxo-3-(4-p... 2 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family 1 4
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335339 CHEMBL1277832 Bioactive SureCN3679895
CFAMM00335341 CHEMBL1277746 Bioactive AGN-PC-03ZB7E
CFAMM00335340 CHEMBL1277833 Bioactive AGN-PC-03ZBE0

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27512 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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