CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25555
Family Name Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-indazol-6-yl)-N-(2-piperidin-4-ylpropan-2-yl)pyrazine-2-carboxamide family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00474872 Functional Category Bioactive
Superfamily Cyclin-A2 and Cyclin-dependent kinase 2 Binder Superfamily 5
Class Class 1185

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
26S proteasome Inhibitor Bortezomib Family 7 65
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
PF-4217903 family 14 65
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 20
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Tyrosine-protein kinase receptor TYRO3 and Tyrosine-protein ki... 13 2
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-N-(5-hyd... 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
P2X purinoceptor 7 inhibitor N-cyano-N'-(2-methylphenyl)-4-[2-... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00474872 CHEMBL2018012 Bioactive 3-amino-6-(1H-indazol-6-yl)-N-(2-piperidin-4-ylpropan-2-yl)pyrazine-2-carboxamide
CFAMM00474873 CHEMBL2018013 Bioactive 3-amino-6-(1H-indazol-7-yl)-N-(2-piperidin-4-ylpropan-2-yl)pyrazine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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