CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2558
Family Name Sodium channel protein type 10 subunit alpha and Sodium channel protein type 2 subunit alpha ligand AGN-PC-09M6KC family
No. of Seeds 3 No. of Other Members 22
Family Centroid CFAMM00335385 Functional Category Bioactive
Superfamily Oxytocin receptor and Sodium channel protein type 9 subunit alpha Binder Superfamily
Class Class 963

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
DNA ligase Inhibitor 7-(4-methoxyphenyl)pteridine-2,4-diol Family 1 4
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(6-me... 2 3
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Histamine H3 receptor and Cytochrome P450 3A4 ligand SureCN822... 3 7
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 1
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Histamine H3 receptor ligand SureCN2784306 family 5 3
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 3 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prothrombin inhibitor AGN-PC-073H0Z family 9 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
5-hydroxytryptamine receptor 1A and D(4) dopamine receptor lig... 1 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-(cy... 3 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Motilin receptor ligand SureCN2768193 family 2 1
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Transient receptor potential cation channel subfamily V member... 6 1
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 4
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 1 1
Glycogen synthase kinase-3 beta and G1/S-specific cyclin-E2 in... 2 0
Cannabinoid receptor 1 ligand N-(1-hydroxy-2,3-dihydro-1H-inde... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
9-(4-methoxyphenyl)-5-(3-methylbutanoyl)-6-pyridin-3-yl-8,9,10... 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335385 CHEMBL1277959 Bioactive AGN-PC-09M6KC
CFAMM00335367 CHEMBL1277877 Bioactive AGN-PC-09M49F
CFAMM00335373 CHEMBL227840 Bioactive SureCN4457176

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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