CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25731
Family Name Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-propan-2-yloxyphenyl)pyridin-2-yl]amino]methyl]phosphonic acid family
No. of Seeds 6 No. of Other Members 0
Family Centroid CFAMM00475605 Functional Category Bioactive
Superfamily Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-isoquinolin-1-yl)-guanidine Superfamily
Class Class 513

Cousin Family NamesSeedsMembers
Peroxisome proliferator-activated receptor gamma Ligand Piogli... 2 29
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Integrin beta-3 and Integrin alpha-V inhibitor (3S,7S)-7-hydro... 5 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-03OERH f... 1 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
4-[(4-pyridin-1-ium-2-ylpiperazin-1-yl)methyl]chromen-2-one NP... 9 0


External ID

Functional Category

Molecule Name

CFAMM00475604 CHEMBL2048242 Bioactive [[[4-(4-cyclobutyloxyphenyl)pyridin-2-yl]amino]-phosphonomethyl]phosphonic acid
CFAMM00475603 CHEMBL2048244 Bioactive [[[4-(4-cyclopentyloxyphenyl)pyridin-2-yl]amino]-phosphonomethyl]phosphonic acid
CFAMM00475602 CHEMBL2088339 Bioactive [[[5-(4-cyclopropyloxyphenyl)pyridin-3-yl]amino]-phosphonomethyl]phosphonic acid
CFAMM00475601 CHEMBL2088338 Bioactive [phosphono-[[5-(4-propan-2-yloxyphenyl)pyridin-3-yl]amino]methyl]phosphonic acid
CFAMM00475600 CHEMBL2088336 Bioactive [[[4-(4-cyclopropyloxyphenyl)pyridin-2-yl]amino]-phosphonomethyl]phosphonic acid
CFAMM00475605 CHEMBL2048241 Bioactive [phosphono-[[4-(4-propan-2-yloxyphenyl)pyridin-2-yl]amino]methyl]phosphonic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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