CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25748
Family Name Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(cyclopropylmethyl)-3-methyl-2-N-(2,4,6-trimethylphenyl)quinoline-2,5-diamine family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00475666 Functional Category Bioactive
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand NGD-8243 Superfamily
Class Class 903

Cousin Family NamesSeedsMembers
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00475667 CHEMBL2049196 Bioactive 5-N-(cyclopropylmethyl)-3-methyl-5-N-(oxan-4-yl)-2-N-(2,4,6-trimethylphenyl)quinoline-2,5-diamine
CFAMM00475666 CHEMBL2049194 Bioactive 5-N,5-N-bis(cyclopropylmethyl)-3-methyl-2-N-(2,4,6-trimethylphenyl)quinoline-2,5-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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