CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25784
Family Name Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3,8-dimethyl-N,N-dipropylquinolin-5-amine family
No. of Seeds 10 No. of Other Members 10
Family Centroid CFAMM00475820 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 and Transcriptional regulator ERG Binder Superfamily
Class Class 1076

Cousin Family NamesSeedsMembers
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Corticotropin-releasing factor receptor 1 and Transcriptional ... 12 5
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 9 0
Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family 1 2


External ID

Functional Category

Molecule Name

CFAMM00475826 CHEMBL2160160 Bioactive 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-fluoro-3-methylquinolin-5-amine
CFAMM00475834 CHEMBL2063375 Bioactive 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-ethyl-N-(2-methoxyethyl)-3,8-dimethylquinolin-5-amine
CFAMM00475819 CHEMBL2063368 Bioactive 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-methyl-N,N-dipropylquinolin-5-amine
CFAMM00475827 CHEMBL2160161 Bioactive 8-chloro-2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-3-methylquinolin-5-amine
CFAMM00475833 CHEMBL2063372 Bioactive 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-3,8-dimethylquinolin-5-amine
CFAMM00475832 CHEMBL2063373 Bioactive N,N-bis(cyclopropylmethyl)-2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3,8-dimethylquinolin-5-amine
CFAMM00475823 CHEMBL2063382 Bioactive 3-chloro-2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methylquinolin-5-amine
CFAMM00475829 CHEMBL2160164 Bioactive 5-(diethylamino)-2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3-methylquinoline-8-carbonitrile
CFAMM00475835 CHEMBL2063374 Bioactive 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-(2-methoxyethyl)-N,3,8-trimethylquinolin-5-amine
CFAMM00475820 CHEMBL2063369 Bioactive 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-3,8-dimethyl-N,N-dipropylquinolin-5-amine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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