CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2582
Family Name 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine receptor 1D ligand 1-[4-[(2-methylphenyl)methyl]piperazin-1-yl]-2-[8-(4-methylpiperazin-1-yl)naphthalen-2-yl]oxyethanone family
No. of Seeds 8 No. of Other Members 0
Family Centroid CFAMM00181909 Functional Category Bioactive
Superfamily Renin Inhibitor Ro-66-1168 Superfamily
Class Class 833

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
Voltage-dependent L-type calcium channel Ligand Sq32,910 Family 1 25
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Renin Inhibitor Ro-66-1168 Family 10 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
5-hydroxytryptamine receptor 1A and D(4) dopamine receptor lig... 1 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335685 CHEMBL129813 Bioactive 1-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]-2-[8-(4-methylpiperazin-1-yl)naphthalen-2-yl]oxyethanone
CFAMM00335684 CHEMBL338015 Bioactive 1-[4-(2,3-dimethoxyphenyl)piperazin-1-yl]-2-[8-(4-methylpiperazin-1-yl)naphthalen-2-yl]oxyethanone
CFAMM00335683 CHEMBL285402 Bioactive AGN-PC-073IAU

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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