CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2583
Family Name Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU family
No. of Seeds 8 No. of Other Members 7
Family Centroid CFAMM00335698 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Prelamin-A/C Binder Superfamily
Class Class 1185

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Smoothened homolog Inhibitor LY2940680 Family 3 18
JAK Inhibitor Momelotinib Family 33 83
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Metabotropic glutamate receptor 5 Ligand N-(1,4-diphenyl-1h-py... 3 35
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Progesterone receptor Ligand GSK-325971A Family 1 13
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 55
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07C64P fa... 8 4
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Adenosine receptor A3 ligand AGN-PC-07N4XY family 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Smoothened homolog inhibitor SureCN1091571 family 2 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-088VMM fa... 1 12
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor 3mvm family 6 1
Mitogen-activated protein kinase 14 inhibitor 3ocg family 6 0
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Smoothened homolog inhibitor (8aS)-N-[2-(3-chlorophenyl)pyrazo... 2 0
Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... 3 39
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 0
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 2 1
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 7 1
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Mitogen-activated protein kinase 14 inhibitor methyl 4-[5-(eth... 3 11
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Aurora kinase A and Aurora kinase B inhibitor 4-amino-N-[4-(th... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor AGN-... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 7
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 5
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Glucocorticoid receptor ligand 5-amino-N-[2-[(1-ethyl-3,4-dihy... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Glucocorticoid receptor ligand 5-amino-N-[(2R)-2-[[(2,6-dichlo... 6 5
Glucocorticoid receptor ligand N-[2-[[[5-amino-1-(4-fluorophen... 1 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family 1 4
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 2
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6479420 family 1 0
MAP kinase-activated protein kinase 2 and Cyclin-dependent kin... 1 0
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00CRQ3 fa... 1 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[5-(2,2-di... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335686 CHEMBL1290745 Bioactive SureCN14097137
CFAMM00335699 CHEMBL370783 Bioactive AGN-PC-00B5TI
CFAMM00335698 CHEMBL1290405 Bioactive AGN-PC-09M6OU
CFAMM00335697 CHEMBL1287825 Bioactive SureCN14097159
CFAMM00335689 CHEMBL1290627 Bioactive SureCN14097141
CFAMM00335688 CHEMBL1290514 Bioactive SureCN14097126
CFAMM00335695 CHEMBL198872 Bioactive AGN-PC-00DNCE
CFAMM00335701 CHEMBL1289077 Bioactive SureCN14097152

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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