CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2584
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D ligand 1,6-dimethyl-5-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]quinolin-2-one family
No. of Seeds 13 No. of Other Members 1
Family Centroid CFAMM00282543 Functional Category Bioactive
Superfamily Kappa-type opioid receptor and Mu-type opioid receptor Ligand 2-(2-methylquinolin-4-ylamino)-n-phenylacetamide Superfamily
Class Class 1105

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Saquinavir Family 64 428
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Transient receptor potential cation channel subfamily V member... 15 158
Neuromedin-K receptor Ligand SB222200 Family 17 235
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Amg 423 family 7 47
Setipiprant family 5 118
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Urotensin-2 receptor Ligand Palosuran Family 4 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
Epidermal growth factor receptor ligand AGN-PC-07Q1HU family 4 17
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Serine/threonine-protein kinase mTOR and DNA-dependent protein... 6 7
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Melanin-concentrating hormone receptor 1 ligand AGN-PC-08W6BO ... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family 8 4
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 5 6
Melanin-concentrating hormone receptor 2 ligand N,N-dimethyl-3... 2 2
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Melanin-concentrating hormone receptor 1 ligand SureCN6198980 ... 13 0
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Motilin receptor ligand SureCN2768052 family 3 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Cholinesterase and Acetylcholinesterase inhibitor [2,2-dimethy... 2 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Telomerase reverse transcriptase inhibitor N-[9-(4-aminoanilin... 1 11
Melanin-concentrating hormone receptor 1 ligand SureCN6200892 ... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Serine/threonine-protein kinase mTOR inhibitor SureCN7919590 f... 1 1
Nuclear receptor ROR-gamma and Prelamin-A/C ligand CHEMBL14461... 1 18
Nonstructural protein 1 and Lysine-specific demethylase 4E inh... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335707 CHEMBL1289277 Bioactive 1,6-dimethyl-5-[2-[(2R)-2-methyl-4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]quinolin-2-one
CFAMM00335705 CHEMBL1290716 Bioactive 1-methyl-5-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]quinolin-2-one
CFAMM00335704 CHEMBL1289617 Bioactive 5-[2-[(2S)-4-(7-fluoro-2-methylquinolin-5-yl)-2-methylpiperazin-1-yl]ethyl]-1,6-dimethylquinolin-2-one
CFAMM00335703 CHEMBL1289394 Bioactive 5-[2-[(2R)-4-(7-fluoro-2-methylquinolin-5-yl)-2-methylpiperazin-1-yl]ethyl]-1-methylquinolin-2-one
CFAMM00335709 CHEMBL1289618 Bioactive 5-[2-[2,2-dimethyl-4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1-methylquinolin-2-one
CFAMM00335708 CHEMBL1289276 Bioactive 5-[2-[4-(7-fluoro-2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1,6-dimethylquinolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26839 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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