CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25854
Family Name Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(5-methoxy-1-methylindol-3-yl)methylidene]-3-pyrazin-2-yl-1H-pyrazol-5-one family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00476212 Functional Category Bioactive
Superfamily Glycogen synthase kinase-3 beta and TGF-beta receptor type-1 Binder Superfamily
Class Class 3127

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
ALK tyrosine kinase receptor and Insulin receptor ligand (4Z,5... 2 29
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Vascular endothelial growth factor receptor 2 ligand (4Z,5Z)-4... 1 3
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 6 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00476212 CHEMBL438970 Bioactive (4Z)-4-[(5-methoxy-1-methylindol-3-yl)methylidene]-3-pyrazin-2-yl-1H-pyrazol-5-one
CFAMM00476211 CHEMBL207600 Bioactive (4Z)-4-[(5-methyl-[1,3]dioxolo[4,5-f]indol-7-yl)methylidene]-3-pyrazin-2-yl-1H-pyrazol-5-one
CFAMM00476210 CHEMBL383435 Bioactive (4Z)-4-[(4-methoxy-1-methylindol-3-yl)methylidene]-3-pyrazin-2-yl-1H-pyrazol-5-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27256 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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