CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2587
Family Name Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 family
No. of Seeds 16 No. of Other Members 32
Family Centroid CFAMM00335750 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Aurora kinase A Inhibitor ABT-348 Family 20 49
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 37 57
XL-888 family 16 85
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Muscarinic acetylcholine receptor M1 Ligand Bo(15)pz Family 4 5
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 9
Sonic hedgehog protein inhibitor 3-chloro-N-[4-(methylamino)cy... 2 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 12
Serine/threonine-protein kinase Chk1 inhibitor 2-(4-methoxyphe... 6 7
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 9 1
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6359092 f... 9 5
Integrin beta-3 and Integrin alpha-IIb inhibitor 3-[[1-(3-pipe... 3 0
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 13 37
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 1
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Caspase-1 inhibitor (3S)-4-oxo-3-[[6-[[4-(quinoxalin-2-ylamino... 5 6
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
Melanin-concentrating hormone receptor 1 ligand 2-(4-methoxyph... 1 0
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Metabotropic glutamate receptor 1 ligand SureCN8238697 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(6-morp... 2 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Histone deacetylase 1 and Potassium voltage-gated channel subf... 3 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Adenosine receptor A1 ligand SureCN1497799 family 2 2
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 1
Calcitonin gene-related peptide type 1 receptor ligand N-(1-me... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335761 CHEMBL1288163 Bioactive 2-(3-cyanophenyl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335760 CHEMBL1288164 Bioactive SureCN3064079
CFAMM00335739 CHEMBL1288305 Bioactive 4-[[(3S)-piperidin-3-yl]amino]-2-(3-pyrrolidin-1-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335766 CHEMBL1288010 Bioactive 2-[3-(hydroxymethyl)phenyl]-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335732 CHEMBL1287864 Bioactive 2-[4-(dimethylcarbamoyl)phenyl]-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335765 CHEMBL1287891 Bioactive SureCN4349674
CFAMM00335731 CHEMBL1287863 Bioactive 2-(3-aminophenyl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335744 CHEMBL1287919 Bioactive 4-[[(3S)-piperidin-3-yl]amino]-2-pyridin-3-ylthieno[3,2-c]pyridine-7-carboxamide
CFAMM00335758 CHEMBL1288102 Bioactive 2-(2,4-difluorophenyl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335764 CHEMBL1287892 Bioactive SureCN3075799
CFAMM00335730 CHEMBL1287862 Bioactive 2-(3-acetamidophenyl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335750 CHEMBL1287920 Bioactive SureCN3070314
CFAMM00335735 CHEMBL1288302 Bioactive SureCN1554796
CFAMM00335762 CHEMBL1288278 Bioactive 2-(4-carbamoylphenyl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335727 CHEMBL1288132 Bioactive 4-[[(3S)-piperidin-3-yl]amino]-2-[4-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335741 CHEMBL1288042 Bioactive 2-(1-benzothiophen-5-yl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46045 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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