CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25884
Family Name Glutamate racemase inhibitor 5-[5-but-2-ynyl-2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-4,6-dioxopyrazolo[3,4-d]pyrimidin-3-yl]-1-methylpyrrole-3-carbonitrile family
No. of Seeds 9 No. of Other Members 8
Family Centroid CFAMM00476362 Functional Category Bioactive
Superfamily Glutamate racemase Binder Superfamily
Class Class 3858

Cousin Family NamesSeedsMembers
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Orexin receptor type 1 and Orexin receptor type 2 ligand AGN-P... 2 24
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase JAK2 and Cytochrome P450 3A4 inhibitor... 1 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Glutamate racemase inhibitor AGN-PC-077KKZ family 6 0
Glutamate racemase inhibitor AGN-PC-077KMZ family 6 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00476360 CHEMBL2087859 Bioactive 5-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-(4-hydroxybut-2-ynyl)-4,6-dioxopyrazolo[3,4-d]pyrimidin-3-yl]-1-methylpyrrole-3-carbonitrile
CFAMM00476353 CHEMBL2087864 Bioactive 5-[2-[(6-chloroquinolin-4-yl)methyl]-5-cyclopropyl-7-(cyclopropylmethyl)-4,6-dioxopyrazolo[3,4-d]pyrimidin-3-yl]-1-methylpyrrole-3-carbonitrile
CFAMM00476359 CHEMBL2087858 Bioactive 5-[2-[(6-chloroquinolin-4-yl)methyl]-5-(cyanomethyl)-7-(cyclopropylmethyl)-4,6-dioxopyrazolo[3,4-d]pyrimidin-3-yl]-1-methylpyrrole-3-carbonitrile
CFAMM00476365 CHEMBL2087865 Bioactive 5-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-(2-hydroxyethyl)-4,6-dioxopyrazolo[3,4-d]pyrimidin-3-yl]-1-methylpyrrole-3-carbonitrile
CFAMM00476357 CHEMBL2087855 Bioactive 5-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-4,6-dioxo-5-[4-(1,2,4-triazol-1-yl)but-2-ynyl]pyrazolo[3,4-d]pyrimidin-3-yl]-1-methylpyrrole-3-carbonitrile
CFAMM00476363 CHEMBL2087860 Bioactive 5-[2-[(6-chloroquinolin-4-yl)methyl]-5,7-bis(cyclopropylmethyl)-4,6-dioxopyrazolo[3,4-d]pyrimidin-3-yl]-1-methylpyrrole-3-carbonitrile
CFAMM00476356 CHEMBL2087857 Bioactive 5-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-(4-morpholin-4-ylbut-2-ynyl)-4,6-dioxopyrazolo[3,4-d]pyrimidin-3-yl]-1-methylpyrrole-3-carbonitrile
CFAMM00476362 CHEMBL2087863 Bioactive 5-[5-but-2-ynyl-2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-4,6-dioxopyrazolo[3,4-d]pyrimidin-3-yl]-1-methylpyrrole-3-carbonitrile
CFAMM00476355 CHEMBL2087856 Bioactive 5-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-4,6-dioxo-5-prop-2-ynylpyrazolo[3,4-d]pyrimidin-3-yl]-1-methylpyrrole-3-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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