CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2591
Family Name Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindol-5-yl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00335804 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Indiplon Family 4 25
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 37 57
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Muscarinic acetylcholine receptor M1 Ligand Bo(15)pz Family 4 5
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 3 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1231206 ... 6 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(4-methoxyphe... 6 7
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 9 1
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
cAMP-dependent protein kinase catalytic subunit beta and cAMP-... 2 9
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Melanocortin receptor 4 ligand AGN-PC-076ANF family 1 0
Metabotropic glutamate receptor 1 ligand SureCN8238697 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 6-ami... 3 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Epidermal growth factor receptor and Vascular endothelial grow... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Coagulation factor X inhibitor SureCN8290907 family 2 2
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Histone deacetylase 1 and Potassium voltage-gated channel subf... 3 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Adenosine receptor A1 ligand SureCN1497799 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 1
MAP kinase-activated protein kinase 2 and Cyclin-dependent kin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335802 CHEMBL1287949 Bioactive 2-(1H-indol-4-yl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335801 CHEMBL1288279 Bioactive 4-[[(3S)-piperidin-3-yl]amino]-2-quinolin-6-ylthieno[3,2-c]pyridine-7-carboxamide
CFAMM00335804 CHEMBL1288304 Bioactive 2-(1-methylindol-5-yl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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