CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2594
Family Name Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 inhibitor 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-[2-(dimethylamino)ethyl]thieno[3,2-c]pyridine-7-carboxamide family
No. of Seeds 8 No. of Other Members 1
Family Centroid CFAMM00329674 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Aurora kinase A Inhibitor ABT-348 Family 20 49
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 37 57
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(4-methoxyphe... 6 7
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 9 1
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Histone deacetylase 1 and Potassium voltage-gated channel subf... 3 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Adenosine receptor A1 ligand SureCN1497799 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335818 CHEMBL1288133 Bioactive 2-(4-methylsulfonylphenyl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00335820 CHEMBL1938655 Bioactive 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-hydroxyethyl)thieno[3,2-c]pyridine-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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