CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26000
Family Name Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide deriv. 38 family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00477069 Functional Category Bioactive
Superfamily Cathepsin S and Cathepsin L1 Binder Superfamily 5
Class Class 252

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Cannabinoid receptor 2 ligand SureCN738026 family 5 68
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 1
Renin inhibitor SureCN9038274 family 3 8
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Cathepsin S and Cathepsin K inhibitor SureCN3011598 family 1 11
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
5-hydroxytryptamine receptor 4 ligand 6-fluoro-N-[[1-[(4-hydro... 1 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 3 5
Cannabinoid receptor 2 ligand SureCN738244 family 1 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 3 2
Coagulation factor VII and Prothrombin inhibitor 2-[(4-carbami... 1 2
Cathepsin S inhibitor SureCN3011651 family 2 2
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00477073 CHEMBL384856 Bioactive SureCN8290918
CFAMM00477069 CHEMBL213610 Bioactive arylaminoethyl amide deriv. 38

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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