CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26156
Family Name Glycogen synthase kinase-3 beta and G1/S-specific cyclin-E2 inhibitor 3-amino-N-(2-methoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00477612 Functional Category Bioactive
Superfamily Prelamin-A/C and DNA polymerase beta Binder Superfamily 18
Class Class 979

Cousin Family NamesSeedsMembers
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
DNA ligase Inhibitor 7-(4-methoxyphenyl)pteridine-2,4-diol Family 1 4
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Adenosine receptor A2b and Adenosine receptor A2a ligand 1-eth... 5 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1


External ID

Functional Category

Molecule Name

CFAMM00477611 CHEMBL2177178 Bioactive 3-amino-N-(3-methoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamide
CFAMM00477612 CHEMBL2177175 Bioactive 3-amino-N-(2-methoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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