CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26207
Family Name Mitogen-activated protein kinase 8 inhibitor 4-amino-6-[2-(carbamoylamino)ethylamino]-5-cyano-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamide family
No. of Seeds 11 No. of Other Members 11
Family Centroid CFAMM00477762 Functional Category Bioactive
Superfamily Adenosine receptor A1 and Adenosine receptor A2b Binder Superfamily 5
Class Class 1481

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 2


External ID

Functional Category

Molecule Name

CFAMM00477764 CHEMBL218219 Bioactive 4-amino-5-cyano-6-(2-hydroxyethylamino)-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamide
CFAMM00477757 CHEMBL221229 Bioactive SureCN1145112
CFAMM00477763 CHEMBL384219 Bioactive 4-amino-5-cyano-6-(1,3-dihydroxypropan-2-ylamino)-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamide
CFAMM00477769 CHEMBL221227 Bioactive 4-amino-5-cyano-6-[[(2S)-1-hydroxypropan-2-yl]amino]-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamide
CFAMM00477762 CHEMBL220810 Bioactive 4-amino-6-[2-(carbamoylamino)ethylamino]-5-cyano-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamide
CFAMM00477755 CHEMBL386010 Bioactive 6-(2-acetamidoethylamino)-4-amino-5-cyano-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamide
CFAMM00477768 CHEMBL218194 Bioactive SureCN1145516
CFAMM00477774 CHEMBL375795 Bioactive SureCN1145541
CFAMM00477754 CHEMBL220658 Bioactive SureCN1145856
CFAMM00477760 CHEMBL434560 Bioactive 4-amino-5-cyano-6-(3-hydroxypropylamino)-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamide
CFAMM00477766 CHEMBL221315 Bioactive 4-amino-6-[(3-amino-3-oxopropyl)amino]-5-cyano-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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