CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2622
Family Name Melanin-concentrating hormone receptor 1 and Cytochrome P450 3A4 ligand AGN-PC-08W6BM family
No. of Seeds 8 No. of Other Members 2
Family Centroid CFAMM00336038 Functional Category Bioactive with Natural Product
Superfamily Melanin-concentrating hormone receptor 1 and Sodium-dependent serotonin transporter Binder Superfamily
Class Class 3193

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Grt 6005/06 family 4 22
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-08W6BO ... 2 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Melanin-concentrating hormone receptor 1 ligand SureCN11425142... 3 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Melanin-concentrating hormone receptor 1 ligand 4-[(2-fluoroph... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Transient receptor potential cation channel subfamily V member... 6 1
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 4
Bile acid receptor ligand SureCN1243717 family 1 4
Telomerase reverse transcriptase inhibitor N-[9-(4-methoxyanil... 2 0
Beta-secretase 1 inhibitor 2-[2-(3-cyanophenyl)-5-(4-phenoxyph... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00336034 CHEMBL1290265 Bioactive AGN-PC-072CSS
CFAMM00336033 CHEMBL1290264 Bioactive AGN-PC-072CVD
CFAMM00336031 CHEMBL1290155 Bioactive SureCN11428728
CFAMM00336038 CHEMBL1289395 Bioactive AGN-PC-08W6BM
CFAMM00336030 CHEMBL1290720 Bioactive AGN-PC-08W6BN
CFAMM00336037 CHEMBL1289396 Bioactive AGN-PC-09M4MF
CFAMM00336029 CHEMBL1289279 Bioactive AGN-PC-09M8CW
CFAMM00336036 CHEMBL1290382 Bioactive AGN-PC-072CVH

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24530 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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