CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26300
Family Name Mitogen-activated protein kinase 14 and Mitogen-activated protein kinase 13 inhibitor SureCN675780 family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00478016 Functional Category Bioactive
Superfamily Androgen receptor and Metabotropic glutamate receptor 1 Binder Superfamily
Class Class 10

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Transient receptor potential cation channel subfamily V member... 16 295
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Amg 423 family 7 47
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
D(4) dopamine receptor ligand (1Z)-1-hydroxyimino-1-(3-methylp... 1 5
Translocator protein inhibitor CHEMBL2331870 family 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-meth... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00478016 CHEMBL220862 Bioactive SureCN675780

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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