CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26406
Family Name Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor (2S)-2-[[9-propan-2-yl-6-(pyridazin-4-ylamino)purin-2-yl]amino]butan-1-ol family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00478504 Functional Category Bioactive
Superfamily Cyclin-A2 and Cyclin-dependent kinase 2 Binder Superfamily 4
Class Class 4985

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Adenosine receptor A1 Ligand SLV320 Family 6 79
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Adenosine deaminase inhibitor AGN-PC-00FYYU family 4 5
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor (2S)-2-[[9-p... 5 5


External ID

Functional Category

Molecule Name

CFAMM00478504 CHEMBL2314435 Bioactive (2S)-2-[[9-propan-2-yl-6-(pyridazin-4-ylamino)purin-2-yl]amino]butan-1-ol
CFAMM00478507 CHEMBL2314436 Bioactive (2R)-3-methyl-2-[[9-propan-2-yl-6-(pyridazin-4-ylamino)purin-2-yl]amino]butan-1-ol
CFAMM00478506 CHEMBL2314437 Bioactive (2R)-2-[[9-propan-2-yl-6-(pyridazin-4-ylamino)purin-2-yl]amino]butan-1-ol
CFAMM00478505 CHEMBL2314434 Bioactive 2-methyl-2-[9-propan-2-yl-6-(pyridazin-4-ylamino)purin-2-yl]propan-1-ol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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