CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26477
Family Name Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00478781 Functional Category Bioactive
Superfamily Receptor tyrosine-protein kinase erbB-2 Inhibitor ARRY-380 Superfamily
Class Class 1256

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00478781 CHEMBL2325695 Bioactive 4-[2-(6-methoxy-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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