CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM265
Family Name Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-5,5-difluoro-2-methyl-4-oxo-6-(pyridine-3-carbonylamino)hexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00309646 Functional Category Bioactive
Superfamily Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-trifluoropropoxy)nicotinamide Superfamily
Class Class 1163

Cousin Family NamesSeedsMembers
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00309647 CHEMBL110364 Bioactive phenyl N-[(2S)-1-[(2S)-2-[[(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-(pyridin-2-ylmethylamino)hexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00309646 CHEMBL106592 Bioactive phenyl N-[(2S)-1-[(2S)-2-[[(3S)-5,5-difluoro-2-methyl-4-oxo-6-(pyridine-3-carbonylamino)hexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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