CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2652
Family Name Vascular endothelial growth factor receptor 2 and Mitogen-activated protein kinase 1 ligand AC1LSBJH family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00336360 Functional Category Bioactive
Superfamily Beta-lactamase and Thyrotropin receptor Binder Superfamily 2
Class Class 3592

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Emedastine Family 5 115
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Translocator protein Inhibitor Emapunil Family 7 89
HCV NS4B protein Inhibitor Clemizole Family 2 43
BIBT986 family 7 96
SB989 family 17 91
Tryptase Inhibitor Babim Family 12 90
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Reverse transcriptase/RNaseH inhibitor 6-FQXPT analog family 2 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Histamine H4 receptor ligand SureCN602132 family 1 8
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Smoothened homolog and Sonic hedgehog protein inhibitor N-cycl... 3 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
C-C chemokine receptor type 3 ligand 5-fluoro-1-[1-[3-(4-fluor... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
C-C chemokine receptor type 5 ligand 1-[4-(3-chlorophenyl)-4-[... 3 1
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Tyrosine-protein kinase Lck inhibitor N-(2-bromophenyl)imidazo... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00336365 CHEMBL524888 Bioactive AGN-PC-077Q7Z
CFAMM00336360 CHEMBL1290361 Bioactive AC1LSBJH

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26190 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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