CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2654
Family Name C-C chemokine receptor type 2 and Potassium voltage-gated channel subfamily H member 2 ligand N-[2-[[(3S,4S)-4-ethoxy-1-(4-phenylcyclohexyl)pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00185305 Functional Category Bioactive
Superfamily Plasmepsin-2 Inhibitor PS-222036 Superfamily
Class Class 2026

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Beta-secretase 1 inhibitor SureCN8292705 family 7 6
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 1 2
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 9
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
5-hydroxytryptamine receptor 1A ligand U93385 family 4 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-[4-... 30 10
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluorome... 4 1
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Beta-secretase 1 inhibitor 1-N-[(1R,2S)-1-[(2R,4S)-4-butoxypip... 5 1
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Beta-secretase 1 inhibitor SureCN8292004 family 1 0
C-C chemokine receptor type 2 ligand AGN-PC-03L0Z6 family 1 1
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Retinal dehydrogenase 1 and 15-hydroxyprostaglandin dehydrogen... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00336381 CHEMBL1290637 Bioactive N-[2-oxo-2-[[(3S,4S)-1-(4-phenylcyclohexyl)-4-propoxypyrrolidin-3-yl]amino]ethyl]-3-(trifluoromethyl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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