CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26541
Family Name Dihydrofolate reductase inhibitor 5-[3-(3-methoxy-5-morpholin-4-ylphenyl)but-1-ynyl]-6-methylpyrimidine-2,4-diamine family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00479258 Functional Category Bioactive
Superfamily Peptide deformylase, mitochondrial Inhibitor Epiroprim Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
SB1518 family 7 103
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Renin and Cytochrome P450 3A4 inhibitor AGN-PC-046RG9 family 8 28
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00479258 CHEMBL2335416 Bioactive 5-[3-(3-methoxy-5-morpholin-4-ylphenyl)but-1-ynyl]-6-methylpyrimidine-2,4-diamine
CFAMM00479259 CHEMBL2335417 Bioactive 6-ethyl-5-[3-(3-methoxy-5-morpholin-4-ylphenyl)but-1-ynyl]pyrimidine-2,4-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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