CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26544
Family Name Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygenase inhibitor 1-[3-[4-[6-chloro-3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenoxy]propyl]-3-[4-(trifluoromethyl)phenyl]urea family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00479263 Functional Category Bioactive
Superfamily Cannabinoid receptor 1 and Glucagon receptor Binder Superfamily
Class Class 1049

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Renin inhibitor AGN-PC-09M4GD family 3 4
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand pheny... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Glucagon receptor ligand SureCN2647807 family 3 7
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 7 4
Beta-secretase 1 and Amyloid beta A4 protein inhibitor SureCN3... 1 5
Metabotropic glutamate receptor 5 ligand AGN-PC-0760YR family 1 0
Tryptophan 5-hydroxylase 1 inhibitor (2S)-2-amino-3-[4-[5-[(3,... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00479265 CHEMBL2336314 Bioactive 1-[3-[4-[6-chloro-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenoxy]propyl]-3-[4-(trifluoromethyl)phenyl]urea
CFAMM00479264 CHEMBL2336306 Bioactive 1-[3-[4-[6-chloro-3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenoxy]propyl]-3-[4-(trifluoromethoxy)phenyl]urea
CFAMM00479263 CHEMBL2336307 Bioactive 1-[3-[4-[6-chloro-3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenoxy]propyl]-3-[4-(trifluoromethyl)phenyl]urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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