CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26608
Family Name Leucine-rich repeat serine/threonine-protein kinase 2 inhibitor 3-(1H-pyrazol-5-yl)-6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazine family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00479489 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor Ligand SGX523 Superfamily
Class Class 922

Cousin Family NamesSeedsMembers
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07R77D fa... 2 7
Metabotropic glutamate receptor 5 ligand SureCN4700553 family 1 0
Cyclooxygenase 2 and Prostaglandin G/H synthase 1 inhibitor Su... 2 1
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-[4-ni... 2 1
Glycogen synthase kinase-3 beta inhibitor pyrazolopyrimidine d... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00479489 CHEMBL2348944 Bioactive 3-(1H-pyrazol-5-yl)-6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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