CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26690
Family Name Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-ylquinolin-4-yl)piperazin-1-yl]benzoate family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00479884 Functional Category Bioactive with Natural Product
Superfamily Beta-lactamase and Methionine aminopeptidase 1 Binder Superfamily
Class Class 447

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prothrombin Inhibitor Ximelegatran Family 8 157
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Setipiprant family 5 118
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Pixantrone family 2 3
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Metabotropic glutamate receptor 5 Ligand 6-phenylethynyl-nicot... 2 26
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Acetylcholinesterase Inhibitor Infractopicrin Family 1 1
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 4
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... 2 10
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
TGF-beta receptor type-1 ligand Methyl 4-(4-(3-(pyridin-2-yl)-... 1 2
Transmembrane prolyl 4-hydroxylase inhibitor 2,2'-Bipyridine-5... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00479881 CHEMBL2375622 Bioactive 4-[4-(2-pyridin-2-ylquinolin-4-yl)piperazin-1-yl]benzaldehyde
CFAMM00479884 CHEMBL2375616 Bioactive ethyl 4-[4-(2-pyridin-2-ylquinolin-4-yl)piperazin-1-yl]benzoate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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