CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2675
Family Name D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-(4-chlorophenoxy)ethyl]-3-phenoxypropan-1-amine family
No. of Seeds 6 No. of Other Members 15
Family Centroid CFAMM00277637 Functional Category Bioactive
Superfamily D(4) dopamine receptor and D(3) dopamine receptor Binder Superfamily
Class Class 60

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Amine oxidase [flavin-containing] A Inhibitor Clorgyline Family 3 6
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Leukotriene A-4 hydrolase Inhibitor DG051 Family 2 8
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
D(4) dopamine receptor ligand AGN-PC-0073PO family 7 10
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 15 11
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 3
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 5 4
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 21
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-(4-... 2 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Neuronal acetylcholine receptor subunit alpha-10 ligand (2S)-2... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 1
Amine oxidase [flavin-containing] B and Membrane primary amine... 1 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00336646 CHEMBL131484 Bioactive N-[2-(4-chlorophenoxy)ethyl]-3-(4-methylphenoxy)propan-1-amine
CFAMM00336639 CHEMBL131997 Bioactive N-[2-(3-chloro-4-methylphenoxy)ethyl]-3-phenoxypropan-1-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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