CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26942
Family Name Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamothioyl]-1,3-diphenylpyrazole-4-carboxamide family
No. of Seeds 7 No. of Other Members 2
Family Centroid CFAMM00480791 Functional Category Bioactive
Superfamily Cyclin-dependent kinase 2 and Cellular tumor antigen p53 Binder Superfamily
Class Class 1555

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Metabotropic glutamate receptor 5 Ligand N-(1,4-diphenyl-1h-py... 3 35
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 16
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 3 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00CRQ3 fa... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00480786 CHEMBL2426388 Bioactive 3-(4-chlorophenyl)-N-[(4-fluorophenyl)carbamothioyl]-1-phenylpyrazole-4-carboxamide
CFAMM00480785 CHEMBL2426389 Bioactive 3-(4-chlorophenyl)-N-[(4-chlorophenyl)carbamothioyl]-1-phenylpyrazole-4-carboxamide
CFAMM00480791 CHEMBL2426381 Bioactive N-[(4-chlorophenyl)carbamothioyl]-1,3-diphenylpyrazole-4-carboxamide
CFAMM00480784 CHEMBL2426393 Bioactive N-[(4-chlorophenyl)carbamothioyl]-3-(4-fluorophenyl)-1-phenylpyrazole-4-carboxamide
CFAMM00480790 CHEMBL2426384 Bioactive N-[(4-fluorophenyl)carbamothioyl]-3-(4-methylphenyl)-1-phenylpyrazole-4-carboxamide
CFAMM00480789 CHEMBL2426385 Bioactive N-[(4-chlorophenyl)carbamothioyl]-3-(4-methylphenyl)-1-phenylpyrazole-4-carboxamide
CFAMM00480788 CHEMBL2426386 Bioactive 3-(4-chlorophenyl)-N-[(4-methylphenyl)carbamothioyl]-1-phenylpyrazole-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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