CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM26968
Family Name Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-methylphenyl)-2-phenylimidazol-1-yl]-1-[4-(4-methoxypyridin-2-yl)piperazin-1-yl]ethanone family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00480872 Functional Category Bioactive
Superfamily Cholecystokinin receptor type A and Prelamin-A/C Binder Superfamily
Class Class 227

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Translocator protein Inhibitor Emapunil Family 7 89
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
Translocator protein inhibitor CHEMBL2331870 family 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Cholecystokinin receptor type A ligand SureCN3132309 family 11 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Somatostatin receptor type 1 ligand AGN-PC-078XQI family 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00480872 CHEMBL2431428 Bioactive 2-[4-(4-fluoro-3-methylphenyl)-2-phenylimidazol-1-yl]-1-[4-(4-methoxypyridin-2-yl)piperazin-1-yl]ethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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