CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27043
Family Name D(2) dopamine receptor and D(3) dopamine receptor ligand methyl 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidine-4-carboxylate family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00481199 Functional Category Bioactive with Human Metabolite
Superfamily Chymase and Stromelysin-3 Binder Superfamily
Class Class 1033

Cousin Family NamesSeedsMembers
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
D(2) dopamine receptor Ligand Sertindole Family 3 173
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Substance-P receptor Ligand GSK424887 Family 8 184
D(1B) dopamine receptor Ligand LE-300 Family 65 452
ABC294640 family 5 75
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Endothelin B receptor Ligand IRL-2500 Family 34 87
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 7 14
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00481202 CHEMBL399396 Bioactive ethyl 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidine-4-carboxylate
CFAMM00481199 CHEMBL246231 Bioactive methyl 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidine-4-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26179 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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