CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27073
Family Name Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-cyclopentyloxy-2,3-dihydro-1H-inden-1-yl]-3,6-diethyl-5-(4-methylpyridin-2-yl)oxypyrazin-2-amine family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00481299 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Inhibitor Pazopanib + Tyverb/tykerb Superfamily
Class Class 1037

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 31
SB1518 family 7 103
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Glucokinase inhibitor 4-methyl-N-[3-phenylmethoxy-5-(pyridin-2... 1 8
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
TGF-beta receptor type-1 ligand 2wou family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00481300 CHEMBL248996 Bioactive 3,6-diethyl-N-[(1R,2S)-2-(2-fluoroethoxy)-2,3-dihydro-1H-inden-1-yl]-5-(6-methylpyrimidin-4-yl)oxypyrazin-2-amine
CFAMM00481299 CHEMBL250815 Bioactive N-[(1R,2S)-2-cyclopentyloxy-2,3-dihydro-1H-inden-1-yl]-3,6-diethyl-5-(4-methylpyridin-2-yl)oxypyrazin-2-amine
CFAMM00481298 CHEMBL400082 Bioactive 2-[[(1R,2S)-1-[[3,6-diethyl-5-(4-methylpyridin-2-yl)oxypyrazin-2-yl]amino]-2,3-dihydro-1H-inden-2-yl]oxy]ethanol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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