CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27086
Family Name Serine/threonine-protein kinase Chk1 inhibitor N'-(8-chloro-3-methyl-2H-pyrazolo[4,3-c]quinolin-4-yl)ethane-1,2-diamine family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00481341 Functional Category Bioactive
Superfamily Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-piperazin-1-yl-quinoline Superfamily
Class Class 2021

Cousin Family NamesSeedsMembers
Benzodiazepine receptor Ligand Midazolam Family 5 160
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
3-phosphoinositide-dependent protein kinase 1 and Rho-associat... 12 11
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 3 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Fibroblast growth factor receptor 1 and Vascular endothelial g... 5 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 2
Melanin-concentrating hormone receptor 1 ligand N-[1-(2,1,3-be... 1 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00481341 CHEMBL250229 Bioactive N'-(8-chloro-3-methyl-2H-pyrazolo[4,3-c]quinolin-4-yl)ethane-1,2-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27759 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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