CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27272
Family Name P2X purinoceptor 7 inhibitor N-cyano-N'-(2-methylphenyl)-4-[2-(5-methylpyrazol-1-yl)acetyl]-3-phenylpiperazine-1-carboximidamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00482021 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and Melanocortin receptor 4 Binder Superfamily
Class Class 843

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 12 108
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 5 11
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 20
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00482021 CHEMBL271213 Bioactive N-cyano-N'-(2-methylphenyl)-4-[2-(5-methylpyrazol-1-yl)acetyl]-3-phenylpiperazine-1-carboximidamide
CFAMM00482020 CHEMBL403965 Bioactive N-cyano-N'-(2-methylphenyl)-4-[2-(3-methylpyrazol-1-yl)acetyl]-3-phenylpiperazine-1-carboximidamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26223 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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