CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2736
Family Name Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN7220958 family
No. of Seeds 52 No. of Other Members 12
Family Centroid CFAMM00142942 Functional Category Bioactive
Superfamily Adenosine receptor A1 and Adenosine receptor A2b Binder Superfamily
Class Class 253

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Vardena... 3 39
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
GP-531 family 1 33
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN1... 6 16
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 17 3
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[4-(5-ethyl-1,2,4... 25 61
Prelamin-A/C inhibitor CHEMBL1501476 family 1 2
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[3-fluoro-4-(5-ph... 10 2
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[4-[5-(cyclopenty... 27 2
Survival motor neuron protein and Microtubule-associated prote... 2 14
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Histamine H3 receptor ligand SureCN7251693 family 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Adenosine receptor A1 and Adenosine receptor A3 ligand SureCN5... 3 1
Adenosine receptor A3 ligand (2Z)-2-(5-methoxy-2-methyl-1H-pyr... 8 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 3 0
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 1 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 13 2
Adenosine receptor A2b and Adenosine receptor A1 ligand (8Z)-8... 3 33
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Histamine H4 receptor ligand AGN-PC-00FEQJ family 2 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 10 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Adenosine receptor A2b and Adenosine receptor A1 ligand N-(1,3... 2 7
Adenosine receptor A1 and Adenosine receptor A2b ligand (4-nit... 8 2
Adenosine receptor A1 and Adenosine receptor A2b ligand (2,5-d... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Glucagon receptor ligand SureCN2647807 family 3 7
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiest... 7 0
Adenosine receptor A2b and Adenosine receptor A1 ligand N-(3,4... 1 8
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 2 0
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Muscarinic acetylcholine receptor M1 and Nuclear factor NF-kap... 1 12
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 2 0
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand 1-eth... 5 2
Adenosine receptor A1 and Adenosine receptor A2b ligand N-[2-[... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 1
P2X purinoceptor 7 inhibitor (7R)-1-[(3,4-difluorophenyl)methy... 1 0
Lysosomal Pro-X carboxypeptidase inhibitor 4-[6-[(2S)-2-(5,6-d... 2 2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Adenosine receptor A2b ligand (8Z)-8-[2-methyl-5-[2-(4-methylp... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00337403 CHEMBL1628266 Bioactive N-(4-cyanophenyl)-2-[4-[2,6-dioxo-1,3-bis(2,2,3,3,3-pentatritiopropyl)-7H-purin-8-yl]phenoxy]acetamide
CFAMM00337419 CHEMBL59084 Bioactive N-[2-(dimethylamino)ethyl]-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
CFAMM00337418 CHEMBL52993 Bioactive N-[2-(dimethylamino)ethyl]-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]-N-methylacetamide
CFAMM00337408 CHEMBL266522 Bioactive N-[2-[(4-bromophenyl)carbamothioylamino]ethyl]-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
CFAMM00337424 CHEMBL293102 Bioactive N-[2-(methylamino)ethyl]-2-[4-(6-oxo-1,3-dipropyl-2-sulfanylidene-7H-purin-8-yl)phenoxy]acetamide
CFAMM00337407 CHEMBL68756 Bioactive (2S)-2,6-diamino-N-[2-[[2-[4-(1,3-diethyl-2,6-dioxo-7H-purin-8-yl)phenoxy]acetyl]amino]ethyl]hexanamide
CFAMM00337422 CHEMBL9720 Bioactive 2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]-N-[2-[(2,3,4,5,6-pentafluorophenyl)carbamothioylamino]ethyl]acetamide
CFAMM00337405 CHEMBL70059 Bioactive (2S)-2,6-diamino-N-[2-[[2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetyl]amino]ethyl]hexanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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