CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27388
Family Name Interstitial collagenase and Matrix metalloproteinase-9 inhibitor (3R,6S)-6-[(4-nitrophenyl)methyl]-1-(quinolin-2-ylmethyl)-3-(sulfanylmethyl)piperazine-2,5-dione family
No. of Seeds 1 No. of Other Members 5
Family Centroid CFAMM00482393 Functional Category Bioactive with Natural Product
Superfamily Prelamin-A/C and Cholinesterase Binder Superfamily 2
Class Class 173

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Saquinavir Family 64 428
Neuromedin-K receptor Ligand SB222200 Family 17 235
CP-18770 family 6 27
Lethal factor Inhibitor GM6001 Family 50 435
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Leucine-rich repeat serine/threonine-protein kinase 2 and Plat... 1 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Cholinesterase and Acetylcholinesterase inhibitor [2,2-dimethy... 2 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL3... 1 9


External ID

Functional Category

Molecule Name

CFAMM00482393 CHEMBL286254 Bioactive (3R,6S)-6-[(4-nitrophenyl)methyl]-1-(quinolin-2-ylmethyl)-3-(sulfanylmethyl)piperazine-2,5-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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