CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27423
Family Name Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 family
No. of Seeds 23 No. of Other Members 18
Family Centroid CFAMM00482603 Functional Category Bioactive
Superfamily Cellular tumor antigen p53 and Acyl-CoA:cholesterol acyltransferase Binder Superfamily
Class Class 875

Cousin Family NamesSeedsMembers
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 2A and Alpha-1A adrenergic recept... 4 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-[2-... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
D(2) dopamine receptor ligand SureCN11039666 family 1 4
Neuropeptide Y receptor type 5 ligand AGN-PC-07CNP8 family 3 2
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00FHC0 f... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2-(dimethyla... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919926 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00482570 CHEMBL44848 Bioactive SureCN8918974
CFAMM00482585 CHEMBL43537 Bioactive SureCN8918671
CFAMM00482599 CHEMBL44318 Bioactive SureCN8918216
CFAMM00482591 CHEMBL46450 Bioactive SureCN8919282
CFAMM00482566 CHEMBL295033 Bioactive SureCN8920437
CFAMM00482583 CHEMBL43603 Bioactive 1-[2-[3-(5-ethyl-4-phenylimidazol-1-yl)propoxy]-6-methylphenyl]-3-(3-methylbutyl)urea
CFAMM00482590 CHEMBL295867 Bioactive SureCN8920817
CFAMM00482589 CHEMBL42296 Bioactive 1-(3-methylbutyl)-3-[2-methyl-6-[3-(4-phenyl-5-propan-2-ylimidazol-1-yl)propoxy]phenyl]urea
CFAMM00482574 CHEMBL441429 Bioactive SureCN8918508
CFAMM00482603 CHEMBL296463 Bioactive SureCN8919280
CFAMM00482564 CHEMBL44863 Bioactive SureCN8918446
CFAMM00482580 CHEMBL42477 Bioactive SureCN8918983
CFAMM00482588 CHEMBL298236 Bioactive SureCN9030569
CFAMM00482602 CHEMBL295171 Bioactive SureCN9031012
CFAMM00482594 CHEMBL295878 Bioactive SureCN8917464
CFAMM00482569 CHEMBL290630 Bioactive SureCN8919005
CFAMM00482587 CHEMBL296852 Bioactive SureCN9030422
CFAMM00482593 CHEMBL297454 Bioactive SureCN8918827
CFAMM00482568 CHEMBL290000 Bioactive SureCN8920624
CFAMM00482586 CHEMBL47095 Bioactive E5324
CFAMM00482600 CHEMBL297770 Bioactive SureCN8918292
CFAMM00482561 CHEMBL42821 Bioactive SureCN8918502
CFAMM00482567 CHEMBL42165 Bioactive SureCN8919943

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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