CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27431
Family Name Endothelin-converting enzyme 1 and Neprilysin inhibitor [[(2S)-5-(2,4-difluorophenyl)-1-(2-naphthalen-1-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00482629 Functional Category Bioactive
Superfamily Neprilysin and Endothelin-converting enzyme 1 Binder Superfamily
Class Class 1787

Cousin Family NamesSeedsMembers
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Endothelin-converting enzyme 1 and Neprilysin inhibitor (2S)-2... 1 8
Neprilysin inhibitor SureCN489232 family 3 9
Matrix metalloproteinase-9 inhibitor (3R)-2-[ethoxy-(4-phenylp... 4 15
Collagenase 3 and Interstitial collagenase inhibitor (4-benzyl... 2 0
Endothelin-converting enzyme 1 and Neprilysin inhibitor [[(2S)... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00482631 CHEMBL37078 Bioactive [[(2S)-5-(2,4-difluorophenyl)-1-(2-naphthalen-2-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid
CFAMM00482629 CHEMBL290868 Bioactive [[(2S)-5-(2,4-difluorophenyl)-1-(2-naphthalen-1-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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