CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27440
Family Name Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit beta-3 ligand alpha3IA family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00482653 Functional Category Bioactive with Natural Product
Superfamily Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit beta-3 ligand alpha3IA Superfamily
Class Class 2449

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Transient receptor potential cation channel subfamily V member... 2 12
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prothrombin inhibitor AGN-PC-073H0Z family 9 6
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Motilin receptor ligand SureCN2768193 family 2 1
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Transient receptor potential cation channel subfamily V member... 6 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 4
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-07PXWQ f... 3 2
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Metabotropic glutamate receptor 2 ligand 1-butyl-4-[3-chloro-4... 4 14
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
Muscleblind-like protein 1 and Lysosomal alpha-glucosidase inh... 2 0
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-0A9UZU fa... 3 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9RLJ family 1 0
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
4-methyl-7-(pyridin-3-ylmethylideneamino)chromen-2-one NP (e)-... 1 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
9-(4-methoxyphenyl)-5-(3-methylbutanoyl)-6-pyridin-3-yl-8,9,10... 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00482654 CHEMBL291335 Bioactive methyl 5-(4-methoxyphenyl)-1-methyl-2-oxo-6-pyridin-3-ylpyridine-3-carboxylate
CFAMM00482653 CHEMBL413325 Bioactive alpha3IA
CFAMM00482651 CHEMBL557266 Bioactive AGN-PC-07C6SP

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26235 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543