CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27464
Family Name Reverse transcriptase/RNaseH inhibitor (4S)-6-fluoro-4-(3-methylbut-1-ynyl)-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00482771 Functional Category Bioactive
Superfamily Reverse transcriptase/RNaseH inhibitor (4S)-6-fluoro-4-(3-methylbut-1-ynyl)-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one Superfamily
Class Class 1799

Cousin Family NamesSeedsMembers
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1-[bis(4-iodophenyl)methyl]-3-(4... 4 13
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 2
Reverse transcriptase/RNaseH inhibitor (4S)-5-chloro-4-(2-cycl... 5 7
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
Reverse transcriptase/RNaseH inhibitor AC1L9SWL family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00482770 CHEMBL292711 Bioactive (4S)-4-but-1-ynyl-5,6-difluoro-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one
CFAMM00482769 CHEMBL303089 Bioactive (4S)-4-(2-cyclopropylethynyl)-6-fluoro-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one
CFAMM00482774 CHEMBL62179 Bioactive (4s)-5,6-difluoro-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1h)-one
CFAMM00482767 CHEMBL62039 Bioactive DPC 963
CFAMM00482773 CHEMBL62104 Bioactive (4S)-4-but-1-ynyl-6-fluoro-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one
CFAMM00482772 CHEMBL64722 Bioactive (4S)-4-(2-cyclopropylethynyl)-5-fluoro-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one
CFAMM00482771 CHEMBL64233 Bioactive (4S)-6-fluoro-4-(3-methylbut-1-ynyl)-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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