CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27500
Family Name Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propan-2-yl)phenyl]-3-[[1-[2-(trifluoromethyl)phenyl]cyclopentyl]methyl]urea family
No. of Seeds 7 No. of Other Members 2
Family Centroid CFAMM00482935 Functional Category Bioactive
Superfamily Acyl-CoA:cholesterol acyltransferase and Sterol O-acyltransferase 1 Binder Superfamily 3
Class Class 4235

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
NMDA receptor Ligand Aptiganel Hcl Family 2 82
Urokinase-type plasminogen activator Inhibitor N-(1-adamantyl)... 2 15
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-[2-(... 5 72
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Cannabinoid receptor 1 Ligand 1-[bis(4-iodophenyl)methyl]-3-(4... 4 13
Kinesin-like protein KIF11 Inhibitor N-(4'-bromo-3,3'-difluoro... 2 0
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C8 inhib... 6 5
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 8 24
C-C chemokine receptor type 2 and C-C chemokine receptor type ... 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Melanin-concentrating hormone receptor 1 ligand 1-[[4-[4-(3-cy... 14 23
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,3,4-trifluorop... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Melanin-concentrating hormone receptor 1 ligand SureCN14265866... 11 2
Inosine-5'-monophosphate dehydrogenase inhibitor 1-[4-chloro-3... 3 5
Inosine-5'-monophosphate dehydrogenase inhibitor 1-(3,4-dichlo... 1 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(3,5... 2 0
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
C-C chemokine receptor type 5 ligand AC1L9YPM family 3 6
Neuropeptide Y receptor type 5 ligand SureCN6214451 family 3 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRYI family 2 0
Melanin-concentrating hormone receptor 1 and Alpha-1A adrenerg... 1 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Sterol O-acyltransferase 1 inhibitor SureCN7565101 family 2 10
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9352718 f... 2 3
Reverse transcriptase/RNaseH inhibitor (4S)-6-fluoro-4-(3-meth... 7 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN13328411 ... 4 2
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9614694 f... 3 14
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00F87B f... 3 1
Acyl-CoA:cholesterol acyltransferase inhibitor tetradecan-2-yl... 2 4
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 2 0
Extracellular calcium-sensing receptor ligand 478963-46-1 family 2 2
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2
Acyl-CoA:cholesterol acyltransferase inhibitor N-[[2,6-di(prop... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN9848375 family 1 0
2,8-dimethyl-N-phenyl-1,2,3,4,4a,9b-hexahydropyrido[4,3-b]indo... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00482931 CHEMBL42890 Bioactive 1-[2,6-di(propan-2-yl)phenyl]-3-[[1-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]cyclopentyl]methyl]urea
CFAMM00482937 CHEMBL74463 Bioactive 1-[2,6-di(propan-2-yl)phenyl]-3-[(2-phenyl-1,3-dihydroinden-2-yl)methyl]urea
CFAMM00482936 CHEMBL416448 Bioactive 1-[[1-[3,5-bis(trifluoromethyl)phenyl]cyclopentyl]methyl]-3-[2,6-di(propan-2-yl)phenyl]urea
CFAMM00482929 CHEMBL46793 Bioactive SureCN9818614
CFAMM00482935 CHEMBL295147 Bioactive 1-[2,6-di(propan-2-yl)phenyl]-3-[[1-[2-(trifluoromethyl)phenyl]cyclopentyl]methyl]urea
CFAMM00482934 CHEMBL432999 Bioactive 1-[2,6-di(propan-2-yl)phenyl]-3-[(1-naphthalen-1-ylcyclopentyl)methyl]urea
CFAMM00482932 CHEMBL43499 Bioactive SureCN9818600

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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