CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27576
Family Name Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quinazoline-4,5'-imidazolidine]-2,2',4'-trione family
No. of Seeds 4 No. of Other Members 16
Family Centroid CFAMM00483288 Functional Category Bioactive with Natural Product
Superfamily Aldose reductase and Calcitonin gene-related peptide type 1 receptor Binder Superfamily
Class Class 1613

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
K-604 family 4 71
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Phospholipase D1 Inhibitor Halopemide Family 17 111
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
Calcitonin gene-related peptide type 1 receptor and Dual speci... 8 4
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
Phospholipase D1 and Phospholipase D2 inhibitor 4-bromo-N-[(2S... 1 2
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Beta-lactamase inhibitor (1R,5S)-4-[(4-carbamoylphenyl)carbamo... 3 2
Aldose reductase inhibitor Spiro-cimqat family 6 8
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Aldose reductase inhibitor AGN-PC-00OGZL family 1 0
Aldose reductase inhibitor SureCN10775957 family 2 2
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00483298 CHEMBL66588 Bioactive AGN-PC-000RZQ
CFAMM00483289 CHEMBL303058 Bioactive 6-bromo-3-methylspiro[1H-quinazoline-4,5'-imidazolidine]-2,2',4'-trione
CFAMM00483295 CHEMBL303779 Bioactive 8-fluoro-3-methylspiro[1H-quinazoline-4,5'-imidazolidine]-2,2',4'-trione
CFAMM00483288 CHEMBL63778 Bioactive (4R)-6-fluoro-3-methylspiro[1H-quinazoline-4,5'-imidazolidine]-2,2',4'-trione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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