CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27590
Family Name Pdk3 protein and [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial inhibitor 4-[(2R)-2-methyl-4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]piperazine-1-carbonyl]benzonitrile family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00483340 Functional Category Bioactive
Superfamily Pdk3 protein and [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Binder Superfamily 2
Class Class 1315

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Bavisant family 9 65
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Pdk3 protein and [Pyruvate dehydrogenase (acetyl-transferring)... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00483340 CHEMBL304292 Bioactive 4-[(2R)-2-methyl-4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]piperazine-1-carbonyl]benzonitrile
CFAMM00483339 CHEMBL316388 Bioactive 4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE
CFAMM00483338 CHEMBL82385 Bioactive (2R)-1-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl]-3,3,3-trifluoro-2-hydroxy-2-methylpropan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27029 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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