CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM276
Family Name RAC-alpha serine/threonine-protein kinase and Cyclin-dependent kinase 2 inhibitor N-[(R)-(3,4-dichlorophenyl)-(1-methylazetidin-3-yl)methyl]isoquinoline-6-carboxamide family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00288284 Functional Category Bioactive
Superfamily ABC294640 Superfamily
Class Class 913

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H... 1 2
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 2 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2
C-C chemokine receptor type 2 ligand SureCN5946889 family 2 6
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
C-C chemokine receptor type 1 ligand N-[(2R)-1-[(4S)-4-(4-chlo... 4 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 3 2
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Substance-K receptor and Substance-P receptor ligand 3,5-dichl... 3 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
KiSS-1 receptor ligand SureCN5132924 family 2 4
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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