CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27640
Family Name Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopropyl-4-(pyridin-2-ylethynyl)-3,4-dihydroquinazolin-2(1h)-one family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00483502 Functional Category Bioactive
Superfamily Reverse transcriptase/RNaseH Binder Superfamily 10
Class Class 2664

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
D(2) dopamine receptor Ligand Sertindole Family 3 173
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 16 295
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Amg 423 family 7 47
ABC294640 family 5 75
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Prothrombin inhibitor SureCN7371121 family 13 3
Transient receptor potential cation channel subfamily V member... 3 1
Metabotropic glutamate receptor 5 ligand [(E)-(1,2-dicyclohexy... 1 4
Prostaglandin E synthase and Aldo-keto reductase family 1 memb... 3 12
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloro-4-fl... 6 7
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Sterol O-acyltransferase 1 inhibitor SureCN7073167 family 4 2
Transient receptor potential cation channel subfamily V member... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00483504 CHEMBL309462 Bioactive AC1L9SW3
CFAMM00483502 CHEMBL309896 Bioactive (4s)-6-chloro-4-cyclopropyl-4-(pyridin-2-ylethynyl)-3,4-dihydroquinazolin-2(1h)-one
CFAMM00483501 CHEMBL417394 Bioactive (4S)-5-chloro-6-fluoro-4-(2-pyridin-2-ylethynyl)-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one
CFAMM00483500 CHEMBL314012 Bioactive AC1L9SVX
CFAMM00483506 CHEMBL311996 Bioactive AC1L9SW0

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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