CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27657
Family Name Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00483569 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and Serine/threonine-protein kinase mTOR Inhibitor BEZ235 Superfamily
Class Class 147

Cousin Family NamesSeedsMembers
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
D(2) dopamine receptor Ligand Sertindole Family 3 173
Transient receptor potential cation channel subfamily V member... 15 158
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Amg 423 family 7 47
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9057529 f... 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00483569 CHEMBL310523 Bioactive AGN-PC-00GCQW
CFAMM00483568 CHEMBL80973 Bioactive SureCN8814547

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24639 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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