CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM27681
Family Name cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhibited 3',5'-cyclic phosphodiesterase A inhibitor 8-ethyl-3H-[1,3]thiazolo[4,5-b][1,6]naphthyridin-2-one family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00483646 Functional Category Bioactive
Superfamily Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibitor 6-phenyl-thieno[3,2-d]pyrimidin-4-ylamine Superfamily
Class Class 1151

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M88D fa... 2 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Cyclin-dependent kinase 6 and Cyclin-dependent kinase 4 inhibi... 1 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00483649 CHEMBL87298 Bioactive 8-methyl-3H-[1,3]thiazolo[4,5-b][1,6]naphthyridin-2-one
CFAMM00483648 CHEMBL311921 Bioactive Win 58993
CFAMM00483647 CHEMBL82745 Bioactive 5-ethyl-6-pyridin-4-yl-3H-[1,3]thiazolo[4,5-b]pyridin-2-one
CFAMM00483646 CHEMBL86200 Bioactive 8-ethyl-3H-[1,3]thiazolo[4,5-b][1,6]naphthyridin-2-one
CFAMM00483645 CHEMBL313940 Bioactive 8-propyl-3H-[1,3]thiazolo[4,5-b][1,6]naphthyridin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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